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Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics

Schmitt, Karen ; Grimm, Amandine ; Dallmann, Robert ; Oettinghaus, Bjoern ; Restelli, Lisa Michelle ; Witzig, Melissa ; Ishihara, Naotada ; Mihara, Katsuyoshi ; Ripperger, Jürgen A. ; Albrecht, Urs ; Frank, Stephan ; Brown, Steven A. ; Eckert, Anne

In: Cell Metabolism, 2018, vol. 27, no. 3, p. 657-666.e5

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly clock controlled. Here we show that these circadian oscillations depend on circadian modification of dynamin-related protein 1 (DRP1), a key mediator of mitochondrial fission. We used a combination of in vitro and in vivo models, including human skin...