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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Kiss, Tamas ; Giles, Cory B. ; Tarantini, Stefano ; Yabluchanskiy, Andriy ; Balasubramanian, Priya ; Gautam, Tripti ; Csipo, Tamas ; Nyúl-Tóth, Ádám ; Lipecz, Agnes ; Szabo, Csaba ; Farkas, Eszter ; Wren, Jonathan D. ; Csiszar, Anna ; Ungvari, Zoltan

In: Published version; http://dx.doi.org/10.1007/s11357-019-00095-x, 2019, p. -

Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide...