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A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, Aurore ; Kirsch, Irving ; Noël, Louis ; Rodondi, Pierre Yves ; Kaptchuk, Ted J. ; Suter, Marc R. ; Décosterd, Isabelle ; Berna, Chantal

In: PLOS ONE, 2019, vol. 14, no. 1, p. e0209851

Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical...