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Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation

Widmer, Jérôme ; Thauvin, Cédric ; Mottasa, Inès ; Nguyen, Van Nga ; Delie, Florence ; Allémann, Eric ; Bourquin, Carole

In: International Journal of Pharmaceutics, 2018, vol. 535, no. 1, p. 444–451

Small-molecule agonists for the Toll-like receptors (TLR) 7 and 8 are effective for the immunotherapy of skin cancer when used as topical agents. Their systemic use has however been largely unsuccessful due to dose-limiting toxicity. We propose a polymer-based nanodelivery system to target resiquimod, a TLR7 ligand, to the lymph node in order to focus the immunostimulatory activity and to...