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Binary cell fate decisions and fate transformation in the Drosophila larval eye

Mishra, Abhishek Kumar ; Tsachaki, Maria ; Rister, Jens ; Ng, June ; Celik, Arzu ; Sprecher, Simon G.

In: PLoS Genet, 2013, vol. 9, no. 12, p. e1004027

Controlling cellular diversity requires a complex interplay of transcription factors. Using the Drosophila larval eye as genetic model we identify distinct mechanisms of how binary cell fate decisions are made, how sensory receptor gene expression is regulated and how cell fate identity is switched during metamorphosis. We show that the transcription factor Senseless fulfills three temporally...