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Arginase-II promotes tumor necrosis Factor-α release from pancreatic acinar cells causing β-cell apoptosis in aging

Xiong, Yuyan ; Yepuri, Gautham ; Necetin, Sevil ; Montani, Jean-Pierre ; Ming, Xiu-Fen ; Yang, Zhihong

In: Diabetes, 2017, vol. 66, no. 6, p. 1636–1649

Aging is associated with glucose intolerance. Arginase-II (Arg-II), the type-II L-arginine- ureahydrolase, is highly expressed in pancreas. However, its role in regulation of pancreatic β-cell function is not known. Here we show that female (not male) mice deficient in Arg-II (Arg-II−/−) are protected from age-associated glucose intolerance and reveal greater glucose induced-insulin...