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Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...