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    Université de Fribourg

    Role of influenza A virus NP acetylation on viral growth and replication

    Giese, Sebastian ; Ciminski, Kevin ; Bolte, Hardin ; Moreira, Étori Aguiar ; Lakdawala, Seema ; Hu, Zehan ; David, Quinnlan ; Kolesnikova, Larissa ; Götz, Veronika ; Zhao, Yongxu ; Dengjel, Jörn ; Chin, Y. Eugene ; Xu, Ke ; Schwemmle, Martin

    In: Nature Communications, 2017, vol. 8, no. 1, p. 1259

    Lysine acetylation is a post-translational modification known to regulate protein functions. Here we identify several acetylation sites of the influenza A virus nucleoprotein (NP), including the lysine residues K77, K113 and K229. Viral growth of mutant virus encoding K229R, mimicking a non-acetylated NP lysine residue, is severely impaired compared to wildtype or the mutant viruses encoding...