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Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients

Coetzee, Jennifer ; Corcoran, Craig ; Prentice, Elizabeth ; Moodley, Mischka ; Mendelson, Marc ; Poirel, Laurent ; Nordmann, Patrice ; Brink, Adrian John

In: South African Medical Journal, 2016, vol. 106, no. 5, p. 449–450

The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase- producing Enterobacteriaceae. The State of the World’s Antibiotics report in 2015 highlighted South Africa (SA)’s increasing incidence of these ‘superbugs’ (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase...