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Innovative preclinical models for pulmonary drug delivery research

Ehrmann, Stephan ; Schmid, Otmar ; Darquenne, Chantal ; Rothen-Rutishauser, Barbara ; Sznitman, Josue ; Yang, Lin ; Barosova, Hana ; Vecellio, Laurent ; Mitchell, Jolyon ; Heuze-Vourc’h, Nathalie

In: Expert Opinion on Drug Delivery, 2020, vol. 17, no. 4, p. 463–478

Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in- silico to in-vitro, ex–vivo and in-vivo, can be implemented.Areas covered: The present review covers in-silico mathematical and computational...