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Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window

Mihov, Yoan ; Hasler, Gregor

In: International Journal of Neuropsychopharmacology, 2016, vol. 19, no. 7, p. -

Metabotropic glutamate receptor 5 in bulimia nervosa

Mihov, Yoan ; Treyer, Valerie ; Akkus, Funda ; Toman, Erika ; Milos, Gabriella ; Ametamey, Simon M. ; Johayem, Anass ; Hasler, Gregor

In: Scientific Reports, 2020, vol. 10, no. 1, p. 6374

Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 matched controls. We measured mGlu5 distribution...

Sustained improvement of negative self-schema after a single ketamine infusion: an open-label study

Hasler, Gregor ; Suker, Samir ; Schoretsanitis, Georgios ; Mihov, Yoan

In: Frontiers in Neuroscience, 2020, vol. 14, p. -

Conventional antidepressants have several important limitations, including a lack of direct effects on negative self-schema, which is at the core of Beck’s cognitive theory of depression. Based on previous studies showing a positive effect of ketamine on negative cognition, we compared reductions in negative self-schema between responders and non-responders to a single infusion of ketamine....