Université de Fribourg

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Petrini, Francesco M. ; Mazzoni, Alberto ; Rigosa, Jacopo ; Giambattistelli, Federica ; Granata, Giuseppe ; Barra, Beatrice ; Pampaloni, Alessandra ; Guglielmelli, Eugenio ; Zollo, Loredana ; Capogrosso, Marco ; Micera, Silvestro ; Raspopovic, Stanisa

In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44

The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...

Université de Fribourg

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Formento, Emanuele ; Minassian, Karen ; Wagner, Fabien ; Mignardot, Jean Baptiste ; Le Goff-Mignardot, Camille G. ; Rowald, Andreas ; Bloch, Jocelyne ; Micera, Silvestro ; Capogrosso, Marco ; Courtine, Gregoire

In: Nature Neuroscience, 2018, vol. 21, no. 12, p. 1728–1741

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount of...

Université de Fribourg

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Moraud, Eduardo Martin ; Zitzewitz, Joachim von ; Miehlbradt, Jenifer ; Wurth, Sophie ; Formento, Emanuele ; DiGiovanna, Jack ; Capogrosso, Marco ; Courtine, Grégoire ; Micera, Silvestro

In: Scientific Reports, 2018, vol. 8, no. 1, p. 76

After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance...