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Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32

Steffens, Michael ; Leu, Costin ; Ruppert, Ann-Kathrin ; Zara, Federico ; Striano, Pasquale ; Robbiano, Angela ; Capovilla, Giuseppe ; Tinuper, Paolo ; Gambardella, Antonio ; Bianchi, Amedeo ; La Neve, Angela ; Crichiutti, Giovanni ; de Kovel, Carolien G.F. ; Kasteleijn-Nolst Trenité, Dorothée ; de Haan, Gerrit-Jan ; Lindhout, Dick ; Gaus, Verena ; Schmitz, Bettina ; Janz, Dieter ; Weber, Yvonne G. ; Becker, Felicitas ; Lerche, Holger ; Steinhoff, Bernhard J. ; Kleefuß-Lie, Ailing A. ; Kunz, Wolfram S. ; Surges, Rainer ; Elger, Christian E. ; Muhle, Hiltrud ; von Spiczak, Sarah ; Ostertag, Philipp ; Helbig, Ingo ; Stephani, Ulrich ; Møller, Rikke S. ; Hjalgrim, Helle ; Dibbens, Leanne M. ; Bellows, Susannah ; Oliver, Karen ; Mullen, Saul ; Scheffer, Ingrid E. ; Berkovic, Samuel F. ; Everett, Kate V. ; Gardiner, Mark R. ; Marini, Carla ; Guerrini, Renzo ; Lehesjoki, Anna-Elina ; Siren, Auli ; Guipponi, Michel ; Malafosse, Alain ; Thomas, Pierre ; Nabbout, Rima ; Baulac, Stephanie ; Leguern, Eric ; Guerrero, Rosa ; Serratosa, Jose M. ; Reif, Philipp S. ; Rosenow, Felix ; Mörzinger, Martina ; Feucht, Martha ; Zimprich, Fritz ; Kapser, Claudia ; Schankin, Christoph J. ; Suls, Arvid ; Smets, Katrin ; De Jonghe, Peter ; Jordanova, Albena ; Caglayan, Hande ; Yapici, Zuhal ; Yalcin, Destina A. ; Baykan, Betul ; Bebek, Nerses ; Ozbek, Ugur ; Gieger, Christian ; Wichmann, Heinz-Erich ; Balschun, Tobias ; Ellinghaus, David ; Franke, Andre ; Meesters, Christian ; Becker, Tim ; Wienker, Thomas F. ; Hempelmann, Anne ; Schulz, Herbert ; Rüschendorf, Franz ; Leber, Markus ; Pauck, Steffen M. ; Trucks, Holger ; Toliat, Mohammad R. ; Nürnberg, Peter ; Avanzini, Giuliano ; Koeleman, Bobby P.C. ; Sander, Thomas

In: Human Molecular Genetics, 2012, vol. 21, no. 24, p. 5359-5372

Considerations for designing chemical screening strategies in plant biology

Serrano, Mario ; Kombrink, Erich ; Meesters, Christian

In: Frontiers in Plant Science - Plant Physiology, 2015, vol. 6, p. 131

Traditionally, biologists regularly used classical genetic approaches to characterize and dissect plant processes. However, this strategy is often impaired by redundancy, lethality or pleiotropy of gene functions, which prevent the isolation of viable mutants. The chemical genetic approach has been recognized as an alternative experimental strategy, which has the potential to circumvent these...