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Bilayer Properties of 1,3-Diamidophospholipids

Weinberger, Andreas ; Tanasescu, Radu ; Stefaniu, Cristina ; Fedotenko, lllya A. ; Favarger, France ; Ishikawa, Takashi ; Brezesinski, Gerald ; Marques, Carlos M. ; Zumbuehl, Andreas

In: Langmuir, 2015, vol. 31, no. 6, p. 1879–1884

A series of 1,3-diamido phosphocholines was synthesized, and their potential to form stable bilayers was investigated. Large and giant unilamellar vesicles produced from these new lipids form a wide variety of faceted liposomes. Factors such as cooling rates and the careful choice of the liposome preparation method influence the formation of facets. Interdigitation was hypothesized as a main...