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Identification of a novel non-desmoglein autoantigen in Pemphigus Vulgaris

Di Lullo, Giulia ; Calabresi, Valentina ; Mariotti, Feliciana ; Zambruno, Giovanna ; Lanzavecchia, Antonio ; Di Zenzo, Giovanni

In: Frontiers in immunology, 2019, vol. 10, p. 1391

Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes characterized by the presence of circulating and tissue-bound autoantibodies against keratinocyte cell surface antigens, specifically desmoglein (Dsg) 1 and 3. The pathogenic role of anti-Dsg antibodies is well-established, while the mechanism of blister formation is only partly defined. We have applied...

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

Bitoun, Emmanuelle ; Micheloni, Alessia ; Lamant, Laurence ; Bonnart, Chrystelle ; Tartaglia-Polcini, Alessandro ; Cobbold, Christian ; Al Saati, Talal ; Mariotti, Feliciana ; Mazereeuw-Hautier, Juliette ; Boralevi, Franck ; Hohl, Daniel ; Harper, John ; Bodemer, Christine ; D'Alessio, Marina ; Hovnanian, Alain

In: Human Molecular Genetics, 2003, vol. 12, no. 19, p. 2417-2430