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MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells

Carrascosa, C. ; Obula, R. G. ; Missiaglia, E. ; Lehr, H.-A. ; Delorenzi, M. ; Frattini, M. ; Rüegg, Curzio ; Mariotti, Agnese

In: Oncogene, 2011, p. -

Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined mechanisms. By analyzing publicly available gene expression profiles of breast carcinomas, we found that MFG-E8 is highly expressed in primary and metastatic breast carcinomas, associated with absent estrogen receptor expression....