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Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

Jacquier, Nicolas ; Choudhary, Vineet ; Mari, Muriel ; Toulmay, Alexandre ; Health and Human Services, Bethesda, USA ; Reggiori, Fulvio ; Schneiter, Roger

In: Journal of Cell Science, 2011, vol. 124, p. 2424-2437

Cells store metabolic energy in the form of neutral lipids that are deposited within lipid droplets (LDs). In this study, we examine the biogenesis of LDs and the transport of integral membrane proteins from the endoplasmic reticulum (ER) to newly formed LDs. In cells that lack LDs, otherwise LD-localized membrane proteins are homogenously distributed in the ER membrane. Under these conditions,...