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Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules

Mallarino, Luisa Estrada ; Engel, Christina ; Ilık, İbrahim Avşar ; Maticzka, Daniel ; Heyl, Florian ; Müller, Barbara ; Yakulov, Toma A. ; Dengjel, Jörn ; Backofen, Rolf ; Akhtar, Asifa ; Walz, Gerd

In: Scientific Reports, 2020, vol. 10, no. 1, p. 15954

Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However, several ciliary proteins, involved in gating access to the cilium, also assume localizations at other cellular sites including the nucleus, where they participate in DNA damage responses to maintain tissue integrity. Molecular insight into how these molecules...