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Engineered hybrid spider silk particles as delivery system for peptide vaccines

Lucke, Matthias ; Mottas, Inès ; Herbst, Tina ; Hotz, Christian ; Römer, Lin ; Schierling, Martina ; M.Herold, Heike ; Slotta, Ute ; Spinetti, Thibaud ; Scheibel, Thomas ; Winter, Gerhard ; Bourquin, Carole ; Engert, Julia

In: Biomaterials, 2018, vol. 172, p. 105–115

The generation of strong T-cell immunity is one of the main challenges for the development of successful vaccines against cancer and major infectious diseases. Here we have engineered spider silk particles as delivery system for a peptide-based vaccination that leads to effective priming of cytotoxic T-cells. The recombinant spider silk protein eADF4(C16) was fused to the antigenic peptide...