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Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment....

Impact of chemical and meteorological boundary and initial conditions on air quality modeling: WRF-Chem sensitivity evaluation for a European domain

Ritter, Mathias ; Müller, Mathias ; Jorba, Oriol ; Parlow, Eberhard ; Liu, L.-J

In: Meteorology and Atmospheric Physics, 2013, vol. 119, no. 1-2, p. 59-70

Evaluation of numerical simulations of CO2 transport in a city block with field measurements

Gartmann, Andres ; Müller, Mathias ; Parlow, Eberhard ; Vogt, Roland

In: Environmental Fluid Mechanics, 2012, vol. 12, no. 2, p. 185-200