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Potency of transgenic effectors for neurogenetic manipulation in Drosophila larvae

Pauls, Dennis ; Essen, Alina von ; Lyutova, Radostina ; Giesen, Lena van ; Rosner, Ronny ; Wegener, Christian ; Sprecher, Simon G.

In: Genetics, 2014, vol. 199, no. 1, p. 25–37

Genetic manipulations of neuronal activity are a cornerstone of studies aimed to identify the functional impact of defined neurons for animal behavior. With its small nervous system, rapid life cycle, and genetic amenability, the fruit fly Drosophila melanogaster provides an attractive model system to study neuronal circuit function. In the past two decades, a large repertoire of elegant genetic...