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Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes

Altirriba, Jordi ; Poher, Anne-Laure ; Caillon, Aurélie ; Arsenijevic, Denis ; Veyrat-Durebex, Christelle ; Lyautey, Jacqueline ; Dulloo, Abdul G. ; Rohner-Jeanrenaud, Françoise

In: Endocrinology, 2014, vol. 155, no. 11, p. 4189–4201

Oxytocin has been suggested as a novel therapeutic against obesity, because it induces weight loss and improves glucose tolerance in diet-induced obese rodents. A recent clinical pilot study confirmed the oxytocin-induced weight-reducing effect in obese nondiabetic subjects. Nevertheless, the mechanisms involved and the impact on the main comorbidity associated with obesity, type 2 diabetes,...