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A genetically encoded biosensor for visualising hypoxia responses in vivo

Misra, Tvisha ; Baccino-Calace, Martin ; Meyenhofer, Felix ; Rodriguez-Crespo, David ; Akarsu, Hatice ; Armenta-Calderón, Ricardo ; Frei, Thomas A. Gorr, Christian ; Cantera, Rafael ; Egger, Boris ; Luschnig, Stefan

In: Biology Open, 2017, vol. 6, no. 2, p. 296–304

Cells experience different oxygen concentrations depending on location, organismal developmental stage, and physiological or pathological conditions. Responses to reduced oxygen levels (hypoxia) rely on the conserved hypoxia-inducible factor 1 (HIF-1). Understanding the developmental and tissue-specific responses to changing oxygen levels has been limited by the lack of adequate tools for...