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CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function

Rivino, Laura ; Gruarin, Paola ; Häringer, Barbara ; Steinfelder, Svenja ; Lozza, Laura ; Steckel, Bodo ; Weick, Anja ; Sugliano, Elisa ; Jarrossay, David ; Kühl, Anja A. ; Loddenkemper, Christoph ; Abrignani, Sergio ; Sallusto, Federica ; Lanzavecchia, Antonio ; Geginat, Jens

In: Journal of experimental medicine, 2010, vol. 207, no. 3, p. 565-577

Interleukin (IL)-10 produced by regulatory T cell subsets is important for the prevention of autoimmunity and immunopathology, but little is known about the phenotype and function of IL-10–producing memory T cells. Human CD4+CCR6+ memory T cells contained comparable numbers of IL-17– and IL-10–producing cells, and CCR6 was induced under both Th17-promoting conditions and upon tolerogenic...