Université de Fribourg

Optogenetic stimulation of basal forebrain parvalbumin neurons activates the default mode network and associated behaviors

Lozano-Montes, Laura ; Dimanico, Marta ; Mazloum, Reza ; Li, Wenxue ; Nair, Jayakrishnan ; Kintscher, Michael ; Schneggenburger, Ralf ; Harvey, Michael ; Rainer, Gregor

In: Cell Reports, 2020, vol. 33, no. 6, p. 108359

Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associated behaviors. Here, we provide causal evidence for a role of BF in DMN regulation, highlighting a prominent role of parvalbumin (PV)...

Université de Fribourg

Stress impacts the regulation neuropeptides in the rat hippocampus and prefrontal cortex

Li, Wenxue ; Papilloud, Aurelie ; Lozano-Montes, Laura ; Zhao, Nan ; Ye, Xueting ; Zhang, Xiaozhe ; Sandi, Carmen ; Rainer, Gregor

In: PROTEOMICS, 2018, vol. 18, no. 7, p. 1700408

Adverse life experiences increase the lifetime risk to several stress‐related psychopathologies, such as anxiety or depressive‐like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked...