Université de Fribourg

Distant heterotopic callosal connections to premotor cortex in non-human primates

Lanz, Florian ; Moret, Véronique ; Ambett, R. ; Cappe, Céline ; Rouiller, Eric M. ; Loquet, Gérard

In: Neuroscience, 2017, vol. 344, p. 56–66

Cortico-cortical connectivity has become a major focus of neuroscience in the last decade but most of the connectivity studies focused on intrahemispheric circuits. Little has been reported about information acquired and processed in the premotor cortex and its functional connection with its homotopic counterpart in the opposite hemisphere via the corpus callosum. In non-human primates...

Université de Fribourg

Refined methodology for implantation of a head fixation device and chronic recording chambers in non-human primates

Lanz, Florian ; Lanz, X. ; Scherly, A. ; Moret, Véronique ; Gaillard, A. ; Gruner, P. ; Hoogewoud, Henri-Marcel ; Belhaj-Saif, Abderraouf ; Loquet, Gérard ; Rouiller, Eric M.

In: Journal of Neuroscience Methods, 2013, vol. 219, no. 2, p. 262–270

The present study was aimed at developing a new strategy to design and anchor custom-fitted implants, consisting of a head fixation device and a chronic recording chamber, on the skull of adult macaque monkeys. This was done without the use of dental resin or orthopedic cement, as these modes of fixation exert a detrimental effect on the bone. The implants were made of titanium or tekapeek and...

Université de Fribourg

Multisensory integration in non-human primates during a sensory-motor task

Lanz, imageFlorian ; Moret, Véronique ; Rouiller, Eric M. ; Loquet, Gérard

In: Frontiers in Human Neuroscience, 2013, vol. 7, p. 799

Daily our central nervous system receives inputs via several sensory modalities, processes them and integrates information in order to produce a suitable behavior. The amazing part is that such a multisensory integration brings all information into a unified percept. An approach to start investigating this property is to show that perception is better and faster when multimodal stimuli are used...

Université de Fribourg

Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks

Meyer, Kaspar ; Rouiller, Eric M. ; Loquet, Gérard

In: Hearing Research, 2007, vol. 228, no. 1-2, p. 144-155

The present study was designed to complete two previous reports [Loquet, G., Rouiller, E.M., 2002. Neural adaptation to pulsatile acoustical stimulation in the cochlear nucleus of the rat. Hear. Res. 171, 72–81; Loquet, G., Meyer, K., Rouiller, E.M., 2003. Effects of intensity of repetitive acoustic stimuli on neural adaptation in the ventral cochlear nucleus of the rat. Exp. Brain Res. 153,...

Université de Fribourg

Développement d'un modèle expérimental d'implant cochléaire incorporant des propriétés d'adaptation neuronale

Loquet, Gérard ; Rouiller, Eric M. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006.

Les travaux de recherche rapportés dans la présente thèse s’intéressent à la fonction auditive qu’elle aborde sous l’angle de la réhabilitation à l’aide d’une prothèse implantée dans la cochlée : l’implant cochléaire. Ce type de prothèse est utilisé depuis une vingtaine d’années et fournit d’ores et déjà à de nombreux patients des conditions d’écoute...

Université de Fribourg

Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis

Meli, Damian N. ; Coimbra, Roney S. ; Erhart, Dominik G. ; Loquet, Gérard ; Bellac, Caroline L. ; Täuber, Martin G. ; Neumann, Ulf ; Leib, Stephen L.

In: Infection and Immunity, 2006, vol. 74, no. 7, p. 3890-3896

Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis....

Université de Fribourg

Matching the neural adaptation in the rat ventral cochlear nucleus produced by artificial (electric) and acoustic stimulation of the cochlea

Loquet, Gérard ; Pelizzone, Marco ; Valentini, Gregory ; Rouiller, Eric M.

In: Audiology and Neuro-Otology, 2004, vol. 9, p. 144-159

To investigate neural adaptive properties, near-field evoked potentials were recorded from a chronically implanted electrode in the ventral cochlear nucleus in awake Long-Evans rats exposed to acoustic stimuli or receiving intracochlear electric stimulation. Stimuli were 250-ms trains of repetitive acoustic clicks (10, 30 and 50 dB SPL) or biphasic electric pulses (30, 50 and 70 µA) with...