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FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Qi, Qibin ; Kilpeläinen, Tuomas O. ; Downer, Mary K. ; Tanaka, Toshiko ; Smith, Caren E. ; Sluijs, Ivonne ; Sonestedt, Emily ; Chu, Audrey Y. ; Renström, Frida ; Lin, Xiaochen ; Ängquist, Lars H. ; Huang, Jinyan ; Liu, Zhonghua ; Li, Yanping ; Asif Ali, Muhammad ; Xu, Min ; Ahluwalia, Tarunveer Singh ; Boer, Jolanda M.A. ; Chen, Peng ; Daimon, Makoto ; Eriksson, Johan ; Perola, Markus ; Friedlander, Yechiel ; Gao, Yu-Tang ; Heppe, Denise H.M. ; Holloway, John W. ; Houston, Denise K. ; Kanoni, Stavroula ; Kim, Yu-Mi ; Laaksonen, Maarit A. ; Jääskeläinen, Tiina ; Lee, Nanette R. ; Lehtimäki, Terho ; Lemaitre, Rozenn N. ; Lu, Wei ; Luben, Robert N. ; Manichaikul, Ani ; Männistö, Satu ; Marques-Vidal, Pedro ; Monda, Keri L. ; Ngwa, Julius S. ; Perusse, Louis ; van Rooij, Frank J.A. ; Xiang, Yong-Bing ; Wen, Wanqing ; Wojczynski, Mary K. ; Zhu, Jingwen ; Borecki, Ingrid B. ; Bouchard, Claude ; Cai, Qiuyin ; Cooper, Cyrus ; Dedoussis, George V. ; Deloukas, Panos ; Ferrucci, Luigi ; Forouhi, Nita G. ; Hansen, Torben ; Christiansen, Lene ; Hofman, Albert ; Johansson, Ingegerd ; Jørgensen, Torben ; Karasawa, Shigeru ; Khaw, Kay-Tee ; Kim, Mi-Kyung ; Kristiansson, Kati ; Li, Huaixing ; Lin, Xu ; Liu, Yongmei ; Lohman, Kurt K. ; Long, Jirong ; Mikkilä, Vera ; Mozaffarian, Dariush ; North, Kari ; Pedersen, Oluf ; Raitakari, Olli ; Rissanen, Harri ; Tuomilehto, Jaakko ; van der Schouw, Yvonne T. ; Uitterlinden, André G. ; Zillikens, M. Carola ; Franco, Oscar H. ; Shyong Tai, E. ; Ou Shu, Xiao ; Siscovick, David S. ; Toft, Ulla ; Verschuren, W.M. Monique ; Vollenweider, Peter ; Wareham, Nicholas J. ; Witteman, Jacqueline C.M. ; Zheng, Wei ; Ridker, Paul M. ; Kang, Jae H. ; Liang, Liming ; Jensen, Majken K. ; Curhan, Gary C. ; Pasquale, Louis R. ; Hunter, David J. ; Mohlke, Karen L. ; Uusitupa, Matti ; Cupples, L. Adrienne ; Rankinen, Tuomo ; Orho-Melander, Marju ; Wang, Tao ; Chasman, Daniel I. ; Franks, Paul W. ; Sørensen, Thorkild I.A. ; Hu, Frank B. ; Loos, Ruth J. F. ; Nettleton, Jennifer A. ; Qi, Lu

In: Human Molecular Genetics, 2014, vol. 23, no. 25, p. 6961-6972

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Speakman, John R. ; Levitsky, David A. ; Allison, David B. ; Bray, Molly S. ; Castro, John M. de ; Clegg, Deborah J. ; Clapham, John C. ; Dulloo, Abdul G. ; Gruer, Laurence ; Haw, Sally ; Hebebrand, Johannes ; Hetherington, Marion M. ; Higgs, Susanne ; Jebb, Susan A. ; Loos, Ruth J. F. ; Luckman, Simon ; Luke, Amy ; Mohammed-Ali, Vidya ; O’Rahilly, Stephen ; Pereira, Mark ; Perusse, Louis ; Robinson, Tom N. ; Rolls, Barbara ; Symonds, Michael E. ; Westerterp-Plantenga, Margriet S.

In: Disease Models & Mechanisms, 2011, vol. 4, p. 733-745

The close correspondence between energy intake and expenditure over prolonged time periods, coupled with an apparent protection of the level of body adiposity in the face of perturbations of energy balance, has led to the idea that body fatness is regulated via mechanisms that control intake and energy expenditure. Two models have dominated the discussion of how this regulation might take place....