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Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts

Shved, Natallia ; Warsow, Gregor ; Eichinger, Felix ; Hoogewijs, David ; Brandt, Simone ; Wild, Peter ; Kretzler, Matthias ; Cohen, Clemens D. ; Lindenmeyer, Maja T.

In: Scientific Reports, 2017, vol. 7, no. 1, p. 8576

Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional mechanisms is involved in development of chronic kidney diseases (CKD). However, it remains unclear how hypoxia-induced transcription factors (HIFs) and subsequent biological processes contribute to CKD development and progression. In our study, genome-wide expression profiles of more than 200 renal ...

Patients with IgA nephropathy exhibit high systemic PDGF-DD levels

Boor, Peter ; Eitner, Frank ; Cohen, Clemens D. ; Lindenmeyer, Maja T. ; Mertens, Peter R. ; Ostendorf, Tammo ; Floege, Jürgen

In: Nephrology Dialysis Transplantation, 2009, vol. 24, no. 9, p. 2755-2762