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Decrease in VEGF expression induces intussusceptive vascular pruning

Hlushchuk, Ruslan ; Ehrbar, Martin ; Reichmuth, Philipp ; Heinimann, Niklas ; Styp-Rekowska, Beata ; Escher, Robert ; Baum, Oliver ; Lienemann, Philipp ; Makanya, Andrew N. ; Keshet, Eli ; Djonov, Valentin

In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, p. 2836-2844

Objective—The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulation are not known.Methods and Results—VEGF165-releasing hydrogels were applied onto the...