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Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation

Mitterer, Valentin ; Murat, Guillaume ; Réty, Stéphane ; Blaud, Magali ; Delbos, Lila ; Stanborough, Tamsyn ; Bergler, Helmut ; Leulliot, Nicolas ; Kressler, Dieter ; Pertschy, Brigitte

In: Nature Communications, 2016, vol. 7, p. 10336

Eukaryotic ribosomes assemble by association of ribosomal RNA with ribosomal proteins into nuclear precursor particles, which undergo a complex maturation pathway coordinated by non-ribosomal assembly factors. Here, we provide functional insights into how successive structural re-arrangements in ribosomal protein S3 promote maturation of the 40S ribosomal subunit. We show that S3 dimerizes...