In: Systematic Biology, 2017, vol. 66, no. 6, p. 950-963
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In: Genetics, 2020, vol. 216, no. 4, p. 1205–1215
Allele frequencies vary across populations and loci, even in the presence of migration. While most differences may be due to genetic drift, divergent selection will further increase differentiation at some loci. Identifying those is key in studying local adaptation, but remains statistically challenging. A particularly elegant way to describe allele frequency differences among populations...
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In: Current Biology, 2020, p. -
Lactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years in multiple human populations. It has been posited that the primary allele causing LP among Eurasians, rs4988235-A [1], only rose to appreciable frequencies during the Bronze and Iron Ages [2, 3], long after humans started consuming milk from...
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In: Biological Conservation, 2020, vol. 241, p. 108326
Pastoralism is spreading in Central Africa, where many protected areas are under consideration to be opened for grazing, in particular hunting zones. Here we document the loss of biodiversity followed by an influx of transhumant pastoralism into previously uninhabited and virtually pristine habitat in the Central African Republic. Our track count and camera trap surveys of 2012, 2016 and...
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In: Systematic Biology, 2017, p. -
Although it is now widely accepted that the rate of phenotypic evolution may not necessarily be constant across large phylogenies, the frequency and phylogenetic position of periods of rapid evolution remain unclear. In his highly influential view of evolution, G. G. Simpson supposed that such evolutionary jumps occur when organisms transition into so-called new adaptive zones, for instance...
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In: Systematic Biology, 2011, vol. 60, no. 6, p. 813-825
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In: Systematic Biology, 2011, vol. 60, no. 3, p. 358-365
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In: Journal of Theoretical Biology, 2017, vol. 420, p. 174–179
The reconstruction of phylogenetic trees from discrete character data typically relies on models that assume the characters evolve under a continuous-time Markov process operating at some overall rate λ. When λ is too high or too low, it becomes difficult to distinguish a short interior edge from a polytomy (the tree that results from collapsing the edge). In this note, we investigate the rate...
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In: Genetics, 2017, vol. 205, no. 1, p. 317–332
While genetic diversity can be quantified accurately from high coverage sequencing data, it is often desirable to obtain such estimates from data with low coverage, either to save costs or because of low DNA quality, as is observed for ancient samples. Here, we introduce a method to accurately infer heterozygosity probabilistically from sequences with average coverage Embedded Image of a...
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In: Genetics, 2016, vol. 203, no. 2, p. 893–904
Methods that bypass analytical evaluations of the likelihood function have become an indispensable tool for statistical inference in many fields of science. These so-called likelihood-free methods rely on accepting and rejecting simulations based on summary statistics, which limits them to low-dimensional models for which the value of the likelihood is large enough to result in manageable...
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