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Biophysics of temporal interference stimulation

Mirzakhalili, Ehsan ; Barra, Beatrice ; Capogrosso, Marco ; Lempka, Scott F.

In: Cell Systems, 2020, vol. 11, no. 6, p. 557-572.e5

Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures. TI represents a potential breakthrough for treating conditions, such as Parkinson’s disease and chronic pain. However, early clinical work on TI stimulation was met with mixed...