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In vivo function of the lipid raft protein flotillin-1 during cd8+ t cell–mediated host surveillance

Ficht, Xenia ; Ruef, Nora ; Stolp, Bettina ; Samson, Guerric P. B. ; Moalli, Federica ; Page, Nicolas ; Merkler, Doron ; Nichols, Ben J. ; Diz-Muñoz, Alba ; Legler,, Daniel F. ; Niggli, Verena

In: The Journal of Immunology, 2019, p. -

Flotillin-1 (Flot1) is an evolutionary conserved, ubiquitously expressed lipid raft– associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II–mediated contractility. Flot1 also accumulates in the uropod of polarized T cells, suggesting an analogous role in T cell migration. In this study, we analyzed morphology and migration...