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Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase

Dechant, Reinhard ; Binda, Matteo ; Lee, Sung Sik ; Pelet, Serge ; Winderickx, Joris ; Peter, Matthias

In: Embo Journal, 2010, vol. 29, no. 15, p. 2515-2526

Glucose is the preferred carbon source for most cell types and a major determinant of cell growth. In yeast and certain mammalian cells, glucose activates the cAMP-dependent protein kinase A (PKA), but the mechanisms of PKA activation remain unknown. Here, we identify cytosolic pH as a second messenger for glucose that mediates activation of the PKA pathway in yeast. We find that cytosolic pH is...