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Final Pre-40S Maturation Depends on the Functional Integrity of the 60S Subunit Ribosomal Protein L3

García-Gómez, Juan J. ; Fernández-Pevida, Antonio ; Lebaron, Simon ; Rosado, Iván V. ; Tollervey, David ; Kressler, Dieter ; Cruz, Jesús de la

In: PLoS Genetics, 2014, vol. 10, no. 3, p. e1004205

Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C] allele, which affects the affinity and function of translation elongation factors, impairs cytoplasmic maturation of 20S pre-rRNA. This was not seen for other mutations in or depletion of L3 or other 60S ribosomal proteins. Surprisingly, pre-40S...