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Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery, Maryse ; Scherz, Valentin ; Jakob, William ; Bandeira, Diane ; Deggim-Messmer, Vanessa ; Lauber-Biason, Anna ; Wildhaber, Johannes ; Falquet, Laurent ; Curtis, Nigel ; Zimmermann, Petra

In: BMJ Open, 2020, vol. 10, no. 6, p. e036275

Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency

Korner, Germaine

In: Brain, 2015, vol. 138, no. 10, p. 2948-2963

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency

Korner, Germaine ; Noain, Daniela ; Ying, Ming ; Hole, Magnus ; Flydal, Marte I. ; Scherer, Tanja ; Allegri, Gabriella ; Rassi, Anahita ; Fingerhut, Ralph ; Becu-Villalobos, Damasia ; Pillai, Samyuktha ; Wueest, Stephan ; Konrad, Daniel ; Lauber-Biason, Anna ; Baumann, Christian R. ; Bindoff, Laurence A. ; Martinez, Aurora ; Thöny, Beat

In: Brain, 2015, vol. 138, no. 10, p. 2948-2963

Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate- limiting step in the synthesis of catecholamines. Mutations in the TH gene encoding tyrosine hydroxylase are associated with the autosomal recessive disorder tyrosine hydroxylase deficiency, which manifests phenotypes varying from infantile parkinsonism and DOPA-responsive dystonia, also termed type A, to...