Université de Fribourg

Innervation of the clavicular part of the deltoid muscle by the lateral pectoral nerve

Larionov, Alexey ; Yotovski, Peter ; Link, Karl ; Filgueira, Luis

In: Clinical Anatomy, 2020, vol. 33, no. 8, p. 1152-1158

The innervation pattern of the clavicular head of the deltoid muscle and its corresponding topography was investigated via cadaveric dissection in the present study, focusing on the lateral pectoral nerve.Materials and methods: Fifty‐eight upper extremities were dissected and the nerve supplies to the deltoid muscle and the variability of the lateral pectoral and axillary nerves, including...

Université de Fribourg

Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome

Larionov, Alexey ; Dahlke, Eileen ; Kunke, Madlen ; Rodriguez, Luis Zanon ; Schiessl, Ina M. ; Magnin, Jean‐Luc ; Kern, Ursula ; Alli, Abdel A. ; Mollet, Geraldine ; Schilling, Oliver ; Castrop, Hayo ; Theilig, Franziska

In: Journal of Cellular and Molecular Medicine, 2019, vol. 23, no. 10, p. 6543–6553

The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The primary dysregulation in sodium handling involves an inappropriate activation of the epithelial sodium channel, ENaC. Plasma proteases in a...

Université de Fribourg

A detailed review on the clinical anatomy of the pectoralis major muscle

Larionov, Alexey ; Yotovski, Peter ; Filgueira, Luis

In: SM Journal of Clinical Anatomy, 2018, vol. 2, no. 3, p. 1015

The pectoralis major is a muscle of the upper limb girdle. This muscle has a unique morphological architectonic and a high rate of clinical applications. However, there is lack of data regarding the morphological and functional interactions of the pectoralis major with other muscle and fascial compartments. According to the applied knowledge, the “Humero-pectoral” morpho-functional...

Université de Fribourg

Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy

Eisele, Nicole ; Klossner, Rahel ; Escher, Geneviève ; Rudloff, Stefan ; Larionov, Alexey ; Theilig, Franziska ; Mohaupt, Markus G. ; Mistry, Hiten D. ; Gennari‐Moser, Carine

In: Journal of the American Heart Association, 2018, p. -

In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears contra‐ intuitive. We hypothesize that an appropriate Na+ intake in pregnancy reduces maternal BP and adapts the renin‐angiotensin system in a...