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    2 results 1
    Université de Fribourg

    Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight

    Anderberg, Rozita H ; Richard, Jennifer E ; Eerola, Kim ; Ferreras, Lorena Lopez ; Nordbeck, Elin Banke ; Hansson, Caroline ; Nissbrandt, Hans ; Berqquist, Filip ; Gribble, Fiona M ; Reimann, Frank ; Wernstedt-Asterholm, Ingrid ; Lamy, Christophe M. ; Skibicka, Karolina P

    In: Diabetes, 2017, p. -

    Glucagon-like peptide-1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as anti-obesity strategies. Surprisingly whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the CNS. Serotonin depletion impaired the ability of...

    Université de Fribourg

    Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion

    Lamy, Christophe M. ; Sanno, Hitomi ; Labouèbe, Gwenaël ; Picard, Alexandre ; Magnan, Christophe ; Chatton, Jean-Yves ; Thorens, Bernard

    In: Cell Metabolism, 2014, vol. 19, no. 3, p. 527–538

    Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular...

    2 results 1