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Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway

Gayral, Stephanie ; Garnotel, Roselyne ; Castaing-Berthou, Audrey ; Blaise, Sebastien ; Fougerat, Anne ; Berge, Elodie ; Montheil, Aurelie ; Malet, Nicole ; Wymann, Matthias P. ; Maurice, Pascal ; Debelle, Laurent ; Martiny, Laurent ; Martinez, Laurent O. ; Pshezhetsky, Alexey V. ; Duca, Laurent ; Laffargue, Muriel

In: Cardiovascular Research, 2014, vol. 102, no. 1, p. 118-127

Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB

Stocker, Hugo ; Andjelkovic, Mirjana ; Oldham, Sean ; Laffargue, Muriel ; Wymann, Matthias P. ; Hemmings, Brian A. ; Hafen, Ernst

In: Science, 2002, vol. 15, no. 5562, p. 2088 - 2091

The phosphoinositide phosphatase PTEN is mutated in many human cancers. Although the role of PTEN has been studied extensively, the relative contributions of its numerous potential downstream effectors to deregulated growth and tumorigenesis remain uncertain. We provide genetic evidence in Drosophila melanogaster for the paramount importance of the protein kinase Akt [also called protein...

Weakening link to colorectal cancer ?

Barbier, Maryse ; Attoub, S. ; Calvez, Ronan ; Laffargue, Muriel ; Jarry, A. ; Mareel, M. ; Altruda, F. ; Gespach, C. ; Wu, D. ; Lu, B. ; Hirsch, E. ; Wymann, Matthias P.

In: Nature, 2001, vol. 413, p. 796

The catalytic α-subunit of the enzyme phosphatidylinositol-3-OH kinase (PI(3)Kα) relays signals from G- protein-coupled receptors at the cell membrane and mediates leukocyte responses to chemokines and chemoattractants1, 2, ³. Sasaki et al.⁴ report that mice that cannot produce PI(3)Kα have a high incidence of colorectal carcinomas, causing weight loss and...