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Xenacoelomorpha survey reveals that all 11 animal homeobox gene classes were present in the first bilaterians

Brauchle, Michael ; Bilican, Adem ; Eyer, Claudia ; Bailly, Xavier ; Martínez, Pedro ; Ladurner, Peter ; Bruggmann, Rémy ; Sprecher, Simon G.

In: Genome Biology and Evolution, 2018, vol. 10, no. 9, p. 2205–2217

Homeodomain transcription factors are involved in many developmental processes across animals and have been linked to body plan evolution. Detailed classifications of these proteins identified 11 distinct classes of homeodomain proteins in animal genomes, each harboring specific sequence composition and protein domains. Although humans contain the full set of classes, Drosophila melanogaster...