Université de Fribourg

GPCR-based dopamine sensors—a detailed guide to inform sensor choice for in vivo imaging

Labouesse, Marie A. ; Cola, Reto B. ; Patriarchi, Tommaso

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8048

Understanding how dopamine (DA) encodes behavior depends on technologies that can reliably monitor DA release in freely-behaving animals. Recently, red and green genetically encoded sensors for DA (dLight, GRAB-DA) were developed and now provide the ability to track release dynamics at a subsecond resolution, with submicromolar affinity and high molecular specificity. Combined with rapid ...