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Label-free biosensor detection of endocrine disrupting compounds using engineered estrogen receptors

La Spina, Rita ; Ferrero, Valentina E. V. ; Aiello, Venera ; Pedotti, Mattia ; Varani, Luca ; Lettieri, Teresa ; Calzolai, Luigi ; Haasnoot, Willem ; Colpo, Pascal

In: Biosensors, 2018, vol. 8, no. 1, p. 1-15

Endocrine Disrupting Compounds (EDCs) are chemical substances shown to interfere with endogenous hormones affecting the endocrine, immune and nervous systems of mammals. EDCs are the causative agents of diseases including reproductive disorders and cancers. This highlights the urgency to develop fast and sensitive methods to detect EDCs, which are detrimental even at very low concentrations....