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    Université de Fribourg

    A microfluidics-based method for measuring neuronal activity in Drosophila chemosensory neurons

    Giesen, Lena van ; Neagu-Maier, G. Larisa ; Kwon, Jae Young ; Sprecher, Simon G.

    In: Nature Protocols, 2016, vol. 11, no. 12, p. 2389–2400

    Monitoring neuronal responses to defined sensory stimuli is a powerful and widely used approach for understanding sensory coding in the nervous system. However, providing precise, stereotypic and reproducible cues while concomitantly recording neuronal activity remains technically challenging. Here we describe the fabrication and use of a microfluidics system that allows precise temporally...

    Université de Fribourg

    A pair of pharyngeal gustatory receptor neurons regulates caffeine-dependent ingestion in drosophila larvae

    Choi, Jaekyun ; Giesen, Lena van ; Choi, Min Sung ; Kang, KyeongJin ; Sprecher, Simon G. ; Kwon, Jae Young

    In: Frontiers in Cellular Neuroscience, 2016, p. 181

    The sense of taste is an essential chemosensory modality that enables animals to identify appropriate food sources and control feeding behavior. In particular, the recognition of bitter taste prevents animals from feeding on harmful substances. Feeding is a complex behavior comprised of multiple steps, and food quality is continuously assessed. We here examined the role of pharyngeal...