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Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes

Luo, Zhipu ; Kelleher, Alan J. ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Shittu, Oluwatosin K. ; Krishnavajhala, Aparna ; Schneiter, Roger ; Lopez, Job E. ; Asojo, Oluwatoyin A.

In: Scientific Reports, 2017, vol. 7, no. 1, p. 15310

Tick-borne relapsing fever (RF) borreliosis is a neglected disease that is often misdiagnosed. RF species circulating in the United States include Borrelia turicatae, which is transmitted by argasid ticks. Environmental adaptation by RF Borrelia is poorly understood, however our previous studies indicated differential regulation of B. turicatae genes localized on the 150 kb linear...