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    2 results 1
    Université de Fribourg

    A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes

    Rinschen, Markus M. ; Gödel, Markus ; Grahammer, Florian ; Zschiedrich, Stefan ; Helmstädter, Martin ; Kretz, Oliver ; Zarei, Mostafa ; Braun, Daniela A. ; Dittrich, Sebastian ; Pahmeyer, Caroline ; Schroder, Patricia ; Teetzen, Carolin ; Gee, HeonYung ; Daouk, Ghaleb ; Pohl, Martin ; Kuhn, Elisa ; Schermer, Bernhard ; Küttner, Victoria ; Boerries, Melanie ; Busch, Hauke ; Schiffer, Mario ; Bergmann, Carsten ; Krüger, Marcus ; Hildebrandt, Friedhelm ; Dengjel, Jörn ; Benzing, Thomas ; Huber, Tobias B.

    In: Cell Reports, 2018, vol. 23, no. 8, p. 2495–2508

    Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets...

    Université de Fribourg

    Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

    Bicker, Frank ; Vasic, Verica ; Horta, Guilherme ; Ortega, Felipe ; Nolte, Hendrik ; Kavyanifar, Atria ; Keller, Stefanie ; Stankovic, Nevenka Dudvarski ; Harter, Patrick N. ; Benedito, Rui ; Lutz, Beat ; Baüerle, Tobias ; Hartwig, Jens ; Baumgart, Jan ; Krüger, Marcus ; Radyushkin, Konstantin ; Alberi, Lavinia ; Berninger, Benedikt ; Schmidt, Mirko H.H.

    In: Nature Communications, 2017, vol. 8, p. ncomms15922

    Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell...

    2 results 1