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PPARgamma in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

Nobs, Samuel Philip ; Natali, Sara ; Pohlmeier, Lea ; Okreglicka, Katarzyna ; Schneider, Christoph ; Kurrer, Michael ; Sallusto, Federica ; Kopf, Manfred

In: Journal of experimental medicine, 2017, vol. 214, no. 10, p. 3015-3035

Type-2 immune responses are well-established drivers of chronic inflammatory diseases, such as asthma, and represent a large burden on public health systems. The transcription factor PPARγ is known to promote M2-macrophage and alveolar macrophage development. Here, we report that PPARγ plays a key role in both T cells and dendritic cells (DCs) for development of type-2 immune responses. It...

Interleukin-6 Gene-Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia

van der Poll, Tom ; Keogh, Christopher V. ; Guirao, Xavier ; Buurman, Wim A. ; Kopf, Manfred ; Lowry, Stephen F.

In: Journal of Infectious Diseases, 1997, vol. 176, no. 2, p. 439-444

Lack of IL‐6 augments inflammatory response but decreases vascular permeability in bacterial meningitis

Paul, Robert ; Koedel, Uwe ; Winkler, Frank ; Kieseier, Bernd C. ; Fontana, Adriano ; Kopf, Manfred ; Hartung, H.‐P ; Pfister, H.‐W

In: Brain, 2003, vol. 126, no. 8, p. 1873-1882

Interleukin-4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses

Cenci, Elio ; Mencacci, Antonella ; Del Sero, Giuseppe ; Bacci, Angela ; Montagnoli, Claudia ; Fè d'Ostiani, Cristiana ; Mosci, Paolo ; Bachmann, Martin ; Bistoni, Francesco ; Kopf, Manfred ; Romani, Luigina

In: Journal of Infectious Diseases, 1999, vol. 180, no. 6, p. 1957-1968