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The Alzheimer’s disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides

Siegel, Gabriele ; Gerber, Hermeto ; Koch, Philipp ; Bruestle, Oliver ; Fraering, Patrick C. ; Rajendran, Lawrence

In: Cell Reports, 2017, vol. 19, no. 10, p. 1967–1976

Alzheimer’s disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ40 is the most abundant form, neurotoxicity is mainly mediated by Aβ42. Sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases gives rise to full-length Aβ (Aβ1-x) and N-terminally truncated Aβ′ (Aβ11-x) whereas cleavage by α- and γ-secretases leads to the shorter...