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Ongoing dissemination of OXA-244 carbapenemase-producing Escherichia coli in Switzerland and their detection

Masseron, Amandine ; Poirel, Laurent ; Falgenhauer, Linda ; Imirzalioglu, Can ; Kessler, Julie ; Chakraborty, Trinad ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2020, vol. 97, no. 3, p. 115059

OXA-244 is a derivative of OXA-48 showing weaker carbapenemase activity, compromising the detection of corresponding producers in clinical laboratories. Since 2017, the Swiss National Reference Center for Emerging Antibiotic Resistance noticed an increased identification of OXA-244-producing Escherichia coli (n=15) within the country. Different methods (biochemical and immunoassay tests,...