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Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)

Ebede, Guy R. ; Ndongo, Joseph T. ; Mbing, Joséphine Ngo ; Kenfack, Hector C. M. ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G.

In: Natural Product Research, 2019, p. 1-9

A new cerebroside, Contortamide (1) together with nine known compounds spegatrine (2), affinisine (3), Nb-methylaffinisine (4), ursolic acid (5), α-amyrin (6), bauerenol acetate (7), lupeol (8), betulinic acid (9) and β-sitosterolglycoside (10) were isolated from the trunk bark of Tabernaemontana contorta Stapf. The new compound 1 showed significant activity against Caco-2 colon cancer...