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Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation

Holzer, Ryan G. ; Park, Eek-Joong ; Li, Ning ; Tran, Helen ; Chen, Monica ; Choi, Crystal ; Solinas, Giovanni ; Karin, Michael

In: Cell, 2011, vol. 147, no. 1, p. 173–184

Saturated fatty acids (FA) exert adverse health effects and are more likely to cause insulin resistance and type 2 diabetes than unsaturated FA, some of which exert protective and beneficial effects. Saturated FA, but not unsaturated FA, activate Jun N-terminal kinase (JNK), which has been linked to obesity and insulin resistance in mice and humans. However, it is unknown how saturated and...

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JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni ; Karin, Michael

In: The FASEB Journal, 2010, p. -

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low-grade inflammation thought to contribute to several metabolic disorders, including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic...

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